Micky van de Ven Brace Ends The Toffees' Run at New Home Ground
The Dutch defender emerged as the first backline player to net twice in a Premier League game for Tottenham since the Belgian defender in spring 2013.
At a glance
The Spurs defender nods into the net twice in opening period
Everton's defender has goal ruled after VAR review
Senegalese midfielder nets final goal in 89th minute
This loss is the Merseyside club's initial at their new ground
The Tottenham defender found the net on two occasions as Spurs prolonged their unbeaten run on the road in the Premier League and handed Everton their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their five previous fixtures at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the conclusion of last season.
But Spurs captain Van de Ven struck twice from corners in the first half to put their strong form at jeopardy, and they were unable to mount a comeback before the midfielder - assisted by ex-Everton forward the Brazilian - nodded in a third to put the game to bed.
The Everton defender thought he had equalized the scores five minutes after the defender's first goal, directing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, failed to convert a handful of opportunities, while Vicario made a series of excellent saves to guarantee Tottenham went five away games without defeat in the Premier League.
But the VAR intervened, instructing the match official to check the goal on the screen and the referee decided that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
The win moves Thomas Frank's team into third place in the division, a handful of points off local foes and table-toppers the Gunners.
The Merseyside club stay in 14th position and sit half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven fulfils duties at each end of pitch
After a uninspiring midweek performance in the European competition against the French side, where they managed a mere two shots on target, the manager opted for the French striker up front instead of ex-Everton forward the Brazilian.
The summer signing was failed to influence the game before being substituted for the substitute after an hour on the pitch, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven converted into an attacking force to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the face of goal for an free Van de Ven to head home.
And Ven de Ven - stepping up as skipper in Cristian Romero's unavailability - added his second in added time as he rose above Jordan Pickford to head home.
The Dutchman was equally impressive in defensive duties, partnering well with his defensive colleague as the duo handled superbly with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Everton lacking striker's instinct
Everton's new home had been a happy hunting ground, but it seems the freshness may have worn off somewhat and supporters headed to the exits after the midfielder's final goal for Spurs.
The end in the team's winning streak at home won't be a major concern for David Moyes, but their attacking woes are.
Beto and the other striker - the Everton's two recognised strikers - had netted just a single goal between them before Sunday's outing.
And they were unable to add to that miserable record on a wet and gloomy night on Merseyside.
The striker's performance was summed up when he chose to overhead kick a golden opportunity from close range, even with having room and opportunity to readjust for a more conventional shot that would have challenged Vicario.
The substitute, too, was unable to influence the game after coming on for the starter in the second half.
It wasn't for a lack of opportunity. Most of the home side's attacks came through the winger and the forward, who tirelessly whipped threatening crosses into the Spurs penalty area.
What next for these two sides?
The Toffees: Moyes' men travel to Sunderland in the top flight on early November at 20:00 GMT.
Tottenham: The London club go to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup tie against Newcastle.